Over 1.5 million people in 45 high-burden countries, including India, are estimated to have had a missed or delayed tuberculosis diagnosis in 2020 due to the disruptions caused by the COVID-19 pandemic, according to a study.
The research, published in the journal BMC Medicine, shows that children may be disproportionately affected in over half of countries analysed, those aged 65 or over in more than two thirds of countries, with sex being a risk factor in almost half of countries.
The team, including researchers from the London School of Hygiene & Tropical Medicine (LSHTM), UK, noted that vulnerable populations in high-burden countries worldwide must be prioritised in efforts to reduce the impact of the COVID-19 pandemic on tuberculosis (TB) care.
“Our results show that in many countries those who already faced the most difficulty in obtaining TB diagnosis and care have suffered worsening access as a result of the pandemic,” said study joint lead author Finn McQuaid, from LSHTM.
“While we look to build back and mitigate the impact COVID-19 has had on those with TB, it’s vital that we focus on those most in need; not just out of a duty to address these inequalities, but to have any hope of ending TB,” McQuaid said.
As many as 195,449 (nearly two lakh) children below the age of 15 years, 1,126,133 (over 11.2 lakh) adults aged 15 to 64 years old and 235,402 (2.3 lakh) older individuals aged 65 years or older had a missed or delayed diagnosis of TB in 2020 as a result of COVID-19 disruptions, they said.
These figures include 511,546 (5.1 lakh) women and 863,916 (8.6 lakh) men.
The researchers modelled trends in TB case reporting to the World Health Organisation (WHO) for 45 high-burden countries between 2013 and 2019. Predictions for 2020 using these models were then compared to actual observations in the same year.
Although the study found no evidence for systemic disparity in risk by age or sex on a global scale, when broken down by country, setting-specific inequalities were revealed.
For example, in over half of countries (57.1 per cent) analysed, children were at a greater risk of having their TB diagnosis delayed or missed due to COVID-19 than adults, the researchers said.
In almost half of countries, sex was predicted to be an influential risk factor. Men, for example, were found to be particularly susceptible to missed or delayed diagnoses in the WHO region of the Americas (namely Peru and Brazil), they said.
These results suggest that the pandemic may have resulted in high numbers of individuals with TB being left untreated and unknowingly spreading infection, with long-term public health ramifications.
Despite being responsible for the second largest number of deaths from an infectious disease worldwide, detection rates for cases of TB are low with inequalities in burden and access to care, notably for men, older individuals and children.
Until now, investigations into disruptions to TB patient care caused by COVID-19 have focused on the overall impact of the pandemic, with little consideration for the effect of potential inequalities, such as those related to age or sex.
The findings from this study may provide vital guidance as to major areas that should be targeted by policy makers to reduce the impacts of the pandemic on global TB burden to ensuring equitable patient care.
“Population groups whose access to TB diagnosis was disproportionately affected by the COVID-19 pandemic should be prioritised in catch-up campaigns,” said study co-author Katherine Horton, also from LSHTM.
“For example, in settings where children have missed diagnoses, school-based strategies may be useful, while gender-sensitive strategies should be implemented in settings where one sex has been relatively under-diagnosed,” Horton added.
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